Cellufine™ HIC

Cellufine™ Hydrophobic Interaction Chromatography Media

Cellufine™ Hydrophobic Interaction Chromatography Media Image

Cellufine™ hydrophobic interaction chromatography (HIC) media are porous chromatography particles, comprising cross-linked cellulose covalently bonded to either a butyl or phenyl functionality via a short spacer.

Factors which affect the hydrophobic interactions of the media include salt concentration, temperature, pH and the presence of surfactants and organic solvents. Typically, the higher the ionic strength (salt concentration), the stronger the hydrophobic bonding. Consequently, the interactions are enhanced by conditions that are the inverse of those for ion exchange chromatography. HIC is, therefore, an effective and complementary tool for separating and purifying substances which are difficult to or impossible to separate by ion exchange chromatography.

Cellufine™ MAX HIC Phenyl media is a next-generation Cellufine™ media with high flow characteristics. Cellufine™ MAX HIC Phenyl media with two types of functional ligand density is available: standard ligand density and low ligand density (LS).


  • High flow rates allow rapid purification and direct scale-up
  • Compatible with a range of solvent systems
  • Ease of packing
  • Resistant to a range of cleaning and elution conditions
  • No shrinkage at high salt concentrations
  • Can be optimized for selectivity
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