Planova™ FG1 Virus Removal Filters

Promise of Unrivaled Performance

Planova™ FG1 was developed to maximize productivity in biopharmaceutical manufacturing processes. Featuring unrivaled rapid filtration, this filter significantly reduces virus filtration time. Even in the event of process interruptions, it maintains robust virus removal performance, achieving an optimal balance of rapid filtration and reliable virus removal capability—two essential qualities for virus removal filters.

Rapid filtration enabling highly efficient processing
Reliable solution for consistent virus removal
Compatibility with CIP (NaOH) and SIP methods

Planova Filter Selection Guide

Features

Documents

Products Specifications

Integrity Testing

Features

Rapid filtration enabling highly efficient processing

Planova FG1 showed >1,000 LMH initial flux at 343 kPa.

Graphs and figures showing the high throughput performance of Planova FG1 at different filtration pressures

Reliable solution for consistent virus removal

Planova FG1 can consistently achieve high virus removal capability, even during extended process pauses. Furthermore, complete clearance can be achieved even with a 120 minutes process pause.

Viral clearance study with PPV and MVM spike in mAb at 196 kPa

Figure showing the mAb solution filtration process using Planova FG1 and the virus removal performance after a 120-minute process pause

Compatibility with CIP (NaOH) and SIP methods

Planova FG1 can withstand a single treatment of either CIP (≤0.5 N NaOH, 20 h) or SIP (≤132 ℃, 30 min).
There was no difference in water flux before and after CIP/SIP.

Table shows change in water flux after CIP (NaOH) and SIP

To demonstrate that CIP or SIP does not affect filter performance, exaggerated CIP/SIP treatment was tested.

CIP treatment: Three cycles of the following CIP treatment: 2 h of filtration with recirculation and 18 h of soak with 1 N NaOH
SIP treatment: Three cycles of the following SIP treatment: 134 ℃ for 30 min

*Except 0.003 and 0.0003 m²filters

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Documents

Technical Documents

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Access technical documents for Planova FG1 filters through the links below.

Brochures

Download brochures on Planova FG1 filters.

Planova FG1 Brochure[PDF:325.1KB]

Product Specifications

			Planova FG1
Effective surface area (m²)			0.3	0.1	0.003	0.0003
Component	Hollow fiber membrane		Hydrophilic modified polyethersulfone
	Housing and headers		Polyphenylsulfone		Polycarbonate
	Sealant		Polyurethane
	O-rings		-- ^a		Silicone
	Nozzle plugs		Silicone		--
	Nozzle caps		--		Silicone
	Ferrule caps		Polycarbonate		--
	Luer lock plugs		--		Polypropylene
	Balloon cap holders		Polycarbonate		--
	Gaskets ^b		Silicone		--
	Balloon caps		Silicone		--
	Clamp bands		Polysulfone	--	--
	Threaded clamps	Clamp bolts	Polypropylene		--
	Threaded clamps	Clamp nuts	Polypropylene		--
Supplied as			Filled with purified water
Sterilization method			Autoclaving
Packaging format			Packed individually in sterilized bags
Operating pressure (TMP)			≤343 kPa (49.7 psi)
Operating pH			3 - 9

^a Not applicable
^b Gaskets are used for connecting quick clamps to nozzles of Planova FG1 filters with effective surface areas of 0.3 and 0.1 m²

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Integrity Testing

Integrity testing of Planova FG1 filters is performed to confirm the integrity of filters used during filtration.
Because the hydrophilic modified polyethersulfone (PES) membrane used in Planova FG1 offers high mechanical strength, the integrity test is simplified.

The leakage test is conducted pre-use and post-use to confirm that the filter is free from gross defects such as pinholes and other membrane damage.

Pre-use: Detect defects that may have occurred during shipping
Post-use: Detect defects that may have developed during filtration