Planova™ S20N Virus Removal Filters
Next-generation Regenerated Cellulose Membrane
For a Wide Range of Biologics
Planova™ S20N is the next generation regenerated cellulose virus filter that’s ready for any challenges. Planova S20N promises “Secure” robust virus removal capability, “Superior” filtration performance for various types of biotherapeutic products and “Simplified” operation for your post-use integrity test. We contribute to further improvement of operations and the greater safety of biologicals.
- "Secure" - Robust Virus Removal Capability
- "Superior" - Processing More, Faster
- "Simplified" - Improved Operational Efficiency
Features
"Secure" - Robust Virus Removal Capability
Planova S20N shows high virus LRV with various viruses and process designs.
"Superior" - Processing More, Faster
The superior regenerated cellulose membrane of Planova S20N withstands higher filtration pressure and resists clogging to deliver stable filterability with higher flux and throughput.
"Simplified" - Improved Operational Efficiency
- Just like other Planova filters, Planova S20N arrives at your site “ready to use” ─ no pre-wetting or sterilization is required prior to use in filtration
- The post-use integrity test is simplified to only a leakage test – no GPT* required
- Planova S20N contributes to operational efficiency during process scale-up and manufacturing
Documents
Spotlight
Download technical leaflets highlighting the key features of Planova S20N filters.
Each Spotlight presents customer and internal data on a subset of features.
Each Spotlight presents customer and internal data on a subset of features.
Planova S20N Spotlight for Biopharmaceuticals Vol.3[PDF:1MB]
Secure virus removal performance — Planova S20N provides trusted viral clearance
Planova S20N Spotlight for Plasma Derivatives Vol.2[PDF:946.6KB]
Higher flux and throughput — Planova S20N processes more and shortens operation time
Planova S20N Spotlight for Plasma Derivatives Vol.1[PDF:866.7KB]
Robust virus removal capability — Planova S20N delivers under various pressure and pause
Technical Documents
Access technical documents for Planova S20N filters through the links below.
Related Presentations
Access presentations on Planova S20N filters through the links below.
Related Videos
Access videos on Planova S20N filters through the links below.
Introduction to Planova S20N
Planova S20N Lab-scale Operation Guide
[Webinar] Planova S20N, the next generation cellulose filter-Key selection factors for nanofilters at early process development stage
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[Webinar] Transforming Your Early Process Development Practices: Planova S20N as Your Pathway to Time and Cost Savings
[Webinar] Planova S20N evaluation on PCC and IgG products
[Webinar] New Generation Planova™ S20N Demonstrates Robust Performance for Multi-Specific Antibodies
Related Publications
Access publications on Planova S20N filters through the links below.
- Performance features of virus removal filters with novel regenerated cellulose hollow fiber membranes
- A design space for the filtration of challenging monoclonal antibodies using Planova™ S20N, a new regenerated cellulose virus removal filter
- Viral clearance in end-to-end integrated continuous process for mAb purification: Total flow-through integrated polishing on two columns connected to virus filtration
Product Specifications
| Planova S20N | ||||||||
|---|---|---|---|---|---|---|---|---|
| Effective surface area (m²) | 4.0 | 1.0 | 0.3 | 0.1 | 0.01 | 0.001 | ||
| Component | Hollow fiber membrane | Cuprammonium regenerated cellulose | ||||||
| Housing and headers | Polycarbonate | |||||||
| Sealant | Polyurethane | |||||||
| O-rings | Silicone | |||||||
| Nozzle plugs | Silicone | -- a | ||||||
| Nozzle caps | -- | Silicone | ||||||
| Ferrule caps | Polycarbonate | -- | ||||||
| Luer lock plugs | -- | Polypropylene | ||||||
| Balloon cap holders | Polycarbonate | -- | ||||||
| Gaskets b | Silicone | -- | ||||||
| Balloon caps | Silicone | -- | ||||||
| Nozzle stoppers | -- | Silicone | -- | |||||
| Clamp bands | Polysulfone | -- | ||||||
| Threaded Clamps | Clamp bolts | Polypropylene | -- | |||||
| Clamp nuts | Polypropylene | -- | ||||||
| Lock nuts | Polycarbonate | -- | ||||||
| Supplied as | Filled with purifled water c | |||||||
| Sterilization method | Autoclaving | |||||||
| Packaging format | Packed individually in sterilized bags | |||||||
| Operating pressure (TMP) | ≤216 kPa (31.3 psi) | |||||||
| Operating pH | 3-9 | |||||||
| Biological safety | Conformance with USP standards for class VI plastics | |||||||
a Not applicable
b Gaskets are used for connecting quick clamps to nozzles of Planova S20N filters with effective surface areas of 4.0, 1.0, 0.3 and 0.1 m2
c Purified water in 4.0 m2 Planova S20N filters contains < 0.1% NaCl
b Gaskets are used for connecting quick clamps to nozzles of Planova S20N filters with effective surface areas of 4.0, 1.0, 0.3 and 0.1 m2
c Purified water in 4.0 m2 Planova S20N filters contains < 0.1% NaCl
Integrity Testing
Integrity testing of Planova S20N filters is performed to confirm the integrity of filters used during filtration.
Because the membrane structure of Planova S20N offers high mechanical strength, the integrity test is simplified.
The leakage test is conducted pre-use and post-use to confirm that the filter is free from gross defects such as pinholes and other membrane damage.
Because the membrane structure of Planova S20N offers high mechanical strength, the integrity test is simplified.
The leakage test is conducted pre-use and post-use to confirm that the filter is free from gross defects such as pinholes and other membrane damage.
- Pre-use: Detect defects that may have occurred during shipping
- Post-use: Detect defects that may have developed during filtration
Related Products & Services
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Ordering Information
Please reference the catalog number when placing orders.
| Effective Surface Area (m²) | Catalog No. | |
|---|---|---|
| Planova S20N | ||
| 4.0 | S20-LF40 | |
| 1.0 | S20-LF10 | |
| 0.3 | S20-3000 | |
| 0.1 | S20-1000 | |
| 0.01 | S20-0100 | |
| 0.001 | S20-0010 |
