Products & Services BioOptimal™ MF-SL Microfilters

Easy and Effective Clarification Made Possible

BioOptimal MF-SL is a hollow fiber microfilter that utilizes an efficient filtration mechanism based on size exclusion and tangential flow filtration. These two aspects allow the filter to smoothly and effectively separate the contents of a solution.
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Applications

Process simplification

BioOptimal MF-SL is able to clarify solutions quickly and completely in a single processing step. Therefore, it simplifies the cell culture clarification process and makes it more cost-effective by eliminating the needs for large investments like centrifuges and expensive disposable items like other depth filters.

Features

Key Features

  • Low TMP (Trans Membrane Pressure)
  • High flux, short filtration time
  • High protein permeability & recovery rate
  • Very low permeate turbidity, less bioburden
  • Low pressure stress at filtration process
 

Basic Information

Tangential Flow Filtration:

The feed fluid flow across the membrane surface creates a sweeping action, preventing quick fouling and extending filtration duration.

Application

Removal of cells from batch culture

TFF-Perfusion cell culture

Monoclonal Antibody (mAb) is one of the main focus categories in biopharmaceuticals. There are several types of cell culture systems such as fed-batch and perfusion culture. Although conventional batch systems are widely accepted in the current process, perfusion based cell culture systems offer the potential to greatly increase cell density and productivity for a long term periods. It is widely accepted that hollow fiber works as a cell separation device in perfusion culture.

Specifications 

Material Specifications
Pore size (μm) 0.4
Hollow fiber ID (mm) 1.4
Hollow fiber material Polysulfone
Housing Polysulfone

Ordering information

Catalog Numbers
Catalog Number Effective Membrane Surface Area Size
MFSL0005 0.005 m²
MFSL0190 0.19 m²
MFSL1000 1 m²
MFSL8000 8 m²