Products & Services Details for Planova™ S20N

Planova™ S20N is the optimal filter for removing viruses in biologicals, from antibody-based therapeutics to plasma-derived products.

Robust Virus Removal Capability

Contributes to the safety and high quality of biologics manufacturing through high virus removability for various viruses and process designs

Processing More, Faster

With a superior regenerated cellulose membrane that can withstand higher filtration pressure, Planova S20N delivers cost-effective performance with higher processing volumes and reduced processing times

Improved Operational Efficiency

Improved operational efficiency during manufacturing by simplifying the postuse integrity test

Integrity tests are conducted on Planova S20N in order to confirm that the hollow fibers are free from damage. Planova S20N using regenerated cellulose enables “simplified” operation for your post-use integrity test due to optimized pressure resistance compared with its Planova N series. It has been confirmed that the absence of pore size distribution shift of the filter under normal filtration conditions. The integrity tests performed by Asahi Kasei Medical during the manufacturing of Planova S20N ensure that only filters with the desired virus retention characteristics are released for shipment to the user. Each filter that passes integrity tests is considered to have the appropriate virus retention characteristics and be free of gross defects such as pinholes.

The integrity test for Planova S20N performed by the user is simple ─ only a leakage test. The leakage test can be performed either as a manual test to detect pressurized air bubbling through the hollow fibers (visual leakage test, VLT) or in an automated procedure to quantitatively measure airflow through the hollow fibers using the Planova Leak Tester (PLT) for Planova S20N filters with an effective surface area of 0.1 m² or more.

Planova S20N must be individually subjected to the leakage test twice both pre-use (before filtration) and post-use (after filtration). The leakage test is performed pre-use to detect defects that may have occurred during shipping and post-use to detect defects that may have formed during the filtration process.